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Biological Psychiatry Cognitive Neuroscience and Neuroimaging
Article . 2018 . Peer-reviewed
License: Elsevier TDM
Data sources: Crossref
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Dynamic Functional Connectivity States Reflecting Psychotic-like Experiences

Authors: Anita D. Barber; Martin A. Lindquist; Pamela DeRosse; Katherine H. Karlsgodt;

Dynamic Functional Connectivity States Reflecting Psychotic-like Experiences

Abstract

Psychotic-like experiences (PLEs) are associated with lower social and occupational functioning, and lower executive function. Emerging evidence also suggests that PLEs reflect neural dysfunction resembling that of psychotic disorders.The present study examined dynamic connectivity related to a measure of PLEs derived from the Achenbach Adult Self-Report, in an otherwise-healthy sample of adults from the Human Connectome Project. A total of 76 PLE-endorsing and 153 control participants were included in the final sample. To characterize network dysfunction, dynamic connectivity states were examined across large-scale resting-state networks using dynamic conditional correlation and k-means clustering.Three dynamic states were identified. The PLE-endorsing group spent more time than the control group in state 1, a state reflecting hyperconnectivity within visual regions and hypoconnectivity within the default mode network, and less time in state 2, a state characterized by robust within-network connectivity for all networks and strong default mode network anticorrelations. Within the PLE-endorsing group, worse executive function was associated with more time spent in and more transitions into state 1 and less time spent in and fewer transitions into state 3.PLEs are associated with altered large-scale brain dynamics, which tip the system away from spending more time in states reflecting more "typical" connectivity patterns toward more time in states reflecting visual hyperconnectivity and default mode hypoconnectivity.

Country
United States
Keywords

Adult, Male, 1.1 Normal biological development and functioning, Biological Psychology, Network, Clinical and health psychology, Executive Function, Clinical Research, Underpinning research, Executive function, Neural Pathways, Connectome, Psychology, Psychotic experiences, Humans, Neurosciences, Brain, Middle Aged, Psychosis, Magnetic Resonance Imaging, Dynamic connectivity, Psychotic Disorders, Default mode network, Biological psychology, Mental health, Female, Nerve Net

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    popularity
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    Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
35
Top 10%
Top 10%
Top 10%
Green
bronze