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Membrane-Mediated Aggregation of Curvature-Inducing Nematogens and Membrane Tubulation

Authors: Ramakrishnan, N.; Sunil Kumar, P.B.; Ipsen, John H.;

Membrane-Mediated Aggregation of Curvature-Inducing Nematogens and Membrane Tubulation

Abstract

The shapes of cell membranes are largely regulated by membrane associated, curvature active, proteins. We use a numerical model of the membrane with elongated membrane inclusions, recently developed by us, which posses spontaneous directional curvatures that could be different along and perpendicular to its long axis. We show that, due to membrane mediated interactions these curvature inducing membrane nematogens can oligomerize spontaneously, even at low concentrations, and change the local shape of the membrane. We demonstrate that for a large group of such inclusions, where the two spontaneous curvatures have equal sign, the tubular conformation and sometime the sheet conformation of the membrane are the common equilibrium shapes. We elucidate the factors necessary for the formation of these {\it protein lattices}. Furthermore, the elastic properties of the tubes, like their compressional stiffness and persistence length are calculated. Finally, we discuss the possible role of nematic disclination in capping and branching of the tubular membranes.

15pages, 8 figures

Country
Denmark
Keywords

Models, Molecular, Protein Structure, Quantitative Biology - Subcellular Processes, Membrane Lipids/chemistry, Biophysics, FOS: Physical sciences, Cell Membrane/chemistry, Condensed Matter - Soft Condensed Matter, Membrane Lipids, Models, Physics - Biological Physics, Subcellular Processes (q-bio.SC), Liquid Crystals/chemistry, Cell Membrane, Membrane Proteins/chemistry, Molecular, Membrane Proteins, Liquid Crystals, Protein Structure, Tertiary, Biological Physics (physics.bio-ph), FOS: Biological sciences, Soft Condensed Matter (cond-mat.soft), Tertiary

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    Top 10%
    influence
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    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
102
Top 10%
Top 10%
Top 1%
Green
hybrid