Coeliac plexus neurolysis (CPN) has been performed for nearly 100 years to try and control pancreatic pain. In recent years endoscopic ultrasound (EUS)-guided CPN has become the preferred technique for this procedure yet relatively little data exists to support its superiority over other methods. Recent studies have demonstrated the potential for direct EUS-guided injection into coeliac ganglia as a means to improve efficacy of CPN. This article describes the technique of EUS-CPN, the evidence supporting its use and recent advances in this procedure.