New anti-inflammatory sterols from a gorgonian Pinnigorgia sp.
Copyright policy )New anti-inflammatory sterols from a gorgonian Pinnigorgia sp.
Chemical investigation on the EtOAc-soluble fraction from the MeOH/DCM extract of a gorgonian Pinnigorgia sp. afforded two new sterols, 11-acetoxy-24S-methyl-3β,5α,6α-trihydroxy-9,11-secocholest-7-en-9-one (1) and 5β,6β-epoxy-(22E,24R)-ergosta-8,22-diene-3β,7β-diol (2). The structures of sterols 1 and 2 were elucidated on the basis of spectroscopic analysis and by comparison of their spectroscopic data with those of related analogues. Both 1 and 2 were shown to significantly inhibit the accumulation of the pro-inflammatory iNOS and COX-2 protein in LPS-stimulated RAW264.7 macrophage cells.
- China Medical University Hospital Taiwan
- China Medical University Taiwan
- Kaohsiung Medical University Taiwan
- National Sun Yat-sen University Taiwan
- National Dong Hwa University Taiwan
Lipopolysaccharides, Cyclooxygenase 2 Inhibitors, Anti-Inflammatory Agents, Nitric Oxide Synthase Type II, Anthozoa, Mice, Sterols, Cyclooxygenase 2, Cell Line, Tumor, Ergosterol, Animals, Secosteroids
Lipopolysaccharides, Cyclooxygenase 2 Inhibitors, Anti-Inflammatory Agents, Nitric Oxide Synthase Type II, Anthozoa, Mice, Sterols, Cyclooxygenase 2, Cell Line, Tumor, Ergosterol, Animals, Secosteroids
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