Antiproliferative activity of salinomycin and its derivatives
Copyright policy )Antiproliferative activity of salinomycin and its derivatives
Antiproliferative activity of seven amides and one benzotriazole ester derivative of salinomycin, a polyether ionophore antibiotic, with recently reported antibacterial activity, are herein described. Salinomycin and the majority of derivatives exhibit potent antiproliferative activity against the drug-resistant cancer cell lines. Moreover almost all derivatives show stronger activity against LoVo/DX cell line than that of unmodified salinomycin.
Molecular Conformation, Antineoplastic Agents, HL-60 Cells, Triazoles, Crystallography, X-Ray, Amides, Polyether Polyketides, Structure-Activity Relationship, Drug Resistance, Neoplasm, Cell Line, Tumor, Humans, Cell Proliferation, Pyrans
Molecular Conformation, Antineoplastic Agents, HL-60 Cells, Triazoles, Crystallography, X-Ray, Amides, Polyether Polyketides, Structure-Activity Relationship, Drug Resistance, Neoplasm, Cell Line, Tumor, Humans, Cell Proliferation, Pyrans
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