Phosphonium lipocations as antiparasitic agents
Copyright policy )Phosphonium lipocations as antiparasitic agents
Phosphonium lipocations were synthesized and evaluated for inhibition of the development of Plasmodium falciparum and Trypanosoma cruzi, etiological agents of malaria and Chagas disease, respectively. Optimal phthalimides and 1,4-naphthoquinone-based lipocations were active in vitro at mid-high nM concentrations against P. falciparum and low μM concentrations against T. cruzi.
- University of Georgia Georgia
- University of Georgia Press United States
- University of California, San Francisco United States
Antiparasitic Agents, Ubiquinone, Trypanosoma cruzi, Plasmodium falciparum, Lipids, Models, Biological, Inhibitory Concentration 50, Organophosphorus Compounds, Cations, Chlorocebus aethiops, Animals, Humans, Chagas Disease, Vero Cells
Antiparasitic Agents, Ubiquinone, Trypanosoma cruzi, Plasmodium falciparum, Lipids, Models, Biological, Inhibitory Concentration 50, Organophosphorus Compounds, Cations, Chlorocebus aethiops, Animals, Humans, Chagas Disease, Vero Cells
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