
pmid: 22209460
Two new oligostilbenes, caragasinins A (5) and B (10), and eight known compounds, kobophenol A (1), (+)-α-viniferin (2), (+)-ampelopsin F (3), pallidol (4), (+)-isoampelopsin F (6), miyabenol C (7), carasinaurone (8) and caraphenol B (9) were isolated from the ethylacetate-soluble extract of the roots of Caragana sinica. The structures of the isolates were determined on the basis of extensive spectroscopic analysis including 1D, 2D NMR and HRESI-MS. These compounds were assessed for antioxidant activities. Caragasinin A (5), caraphenol B (9), and caragasinin B (10) showed moderate DPPH scavenging activity and lipid peroxidation inhibitory activities with IC(50) values ranging from 34.7±1.0 to 89.1±2.3μM.
Dose-Response Relationship, Drug, Indans, Stilbenes, Molecular Conformation, Stereoisomerism, Lipid Peroxidation, Resorcinols, Plant Roots, Antioxidants, Caragana
Dose-Response Relationship, Drug, Indans, Stilbenes, Molecular Conformation, Stereoisomerism, Lipid Peroxidation, Resorcinols, Plant Roots, Antioxidants, Caragana
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