Novel poly(ADP-ribose) polymerase-1 inhibitors

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2007 English Publisher:Elsevier BVJournal:Bioorganic & Medicinal Chemistry Letters, volume 22, pages 222-224 (issn: 0960-894X,

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Authors: Derek, Dunn; Jean, Husten; Mark A, Ator; Sankar, Chatterjee;

doi: 10.1016/j.bmcl.2011.11.032 , 10.1016/j.bmcl.2006.10.010

pmid: 22153339 , 17074482

Novel poly(ADP-ribose) polymerase-1 inhibitors

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Abstract

Synthesis and activity of a series of 3-aroyl-derived analogs of novel pyrrolocarbazole 1 as poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors are disclosed.

Related Organizations

Cephalon
United States

Keywords

Magnetic Resonance Spectroscopy, Chemistry, Pharmaceutical, Carbazoles, Poly (ADP-Ribose) Polymerase-1, Antineoplastic Agents, Poly(ADP-ribose) Polymerase Inhibitors, NAD, PC12 Cells, Recombinant Proteins, Rats, Structure-Activity Relationship, Thiazoles, Inhibitory Concentration 50, Models, Chemical, Drug Design, Neoplasms, Animals, Humans, Indicators and Reagents, Enzyme Inhibitors, DNA Damage

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