The activity of dispiro peroxides against Fasciola hepatica
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Wang, Xiaofang; Zhao, Qingjie; Vargas, Mireille; Dong, Yuxiang; Sriraghavan, Kamaraj; Keiser, Jennifer; Vennerstrom, Jonathan L.;
The activity of dispiro peroxides against Fasciola hepatica
Dispiro 1,2,4-trioxanes and 1,2,4,5-tetraoxanes had superior efficacy against Fasciola hepatica than the corresponding ozonides (1,2,4-trioxolanes). For highest efficacy, spiroadamantane and carboxymethyl substructures were required. Three compounds completely cured F. hepatica-infected mice at single oral doses of 50mg/kg and two were partially curative at single doses of 25mg/kg.
Switzerland
- University of Basel Switzerland
- Nebraska Medical Center United States
- Swiss Tropical and Public Health Institute Switzerland
- University of Nebraska Medical Center United States
Dose-Response Relationship, Drug, Molecular Structure, Stereoisomerism, Fasciola hepatica, Mice, Heterocyclic Compounds, Animals, Spiro Compounds, Tetraoxanes
Dose-Response Relationship, Drug, Molecular Structure, Stereoisomerism, Fasciola hepatica, Mice, Heterocyclic Compounds, Animals, Spiro Compounds, Tetraoxanes
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).31 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
selected citations
Citations provided by BIP!
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
Citations provided by BIP!popularityPopularity provided by BIP!
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
Popularity provided by BIP! 31
Top 10%
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