Molecular modeling and UV–vis spectroscopic studies on the mechanism of action of reversed chloroquine (RCQ)
Copyright policy )Molecular modeling and UV–vis spectroscopic studies on the mechanism of action of reversed chloroquine (RCQ)
Reversed chloroquine (RCQ) is a multiple ligand compound active against chloroquine-sensitive and resistant falciparum malaria. It is composed by a 4-aminoquinoline moiety (like that present in chloroquine (CQ)) joined to imipramine (IMP), a modulating agent that also showed intrinsic antiplasmodial activity against Brazilian Plasmodium falciparum isolates resistant to CQ. Molecular modeling and ultraviolet-visible spectroscopy (UV-vis) studies strongly suggest that the interaction between RCQ and heme is predominant through the quinoline moiety in a mechanism of action similar to that observed for CQ.
- UNIVERSIDADE DE SAO PAULO Brazil
- Universidade de São Paulo Brazil
- Universidade de Sao Paolo Brazil
Imipramine, Organic Chemistry, Clinical Biochemistry, Plasmodium falciparum, Pharmaceutical Science, Antimalarial, Chloroquine, Heme, Hydrogen-Ion Concentration, Molecular Dynamics Simulation, Biochemistry, Antimalarials, Dibenzazepines, Multiple ligand, Drug Discovery, Aminoquinolines, Molecular Medicine, Hemin, Spectrophotometry, Ultraviolet, Reversed chloroquine, Molecular Biology
Imipramine, Organic Chemistry, Clinical Biochemistry, Plasmodium falciparum, Pharmaceutical Science, Antimalarial, Chloroquine, Heme, Hydrogen-Ion Concentration, Molecular Dynamics Simulation, Biochemistry, Antimalarials, Dibenzazepines, Multiple ligand, Drug Discovery, Aminoquinolines, Molecular Medicine, Hemin, Spectrophotometry, Ultraviolet, Reversed chloroquine, Molecular Biology
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