<script type="text/javascript">
<!--
document.write('<div id="oa_widget"></div>');
document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=undefined&type=result"></script>');
-->
</script>

COPY SCRIPT

For further information contact us at helpdesk@openaire.eu

Spiropiperidine CCR5 antagonists

descriptionPublicationkeyboard_double_arrow_right Article 01 Sep 2009Publisher:Elsevier BVJournal:Bioorganic & Medicinal Chemistry Letters, volume 19, pages 5,401-5,406 (issn: 0960-894X,

Authors: Pamela Berry; Gabrielle Heilek; Changhua Ji; Marianna Dioszegi; Shelley K. Gleason; Ferenc Makra; Eun Kyung Lee; +11 Authors

doi: 10.1016/j.bmcl.2009.07.122

pmid: 19674898

Spiropiperidine CCR5 antagonists

- Summary
- Subjects
- Related research
  (1)
- Metrics

Abstract

A novel series of CCR5 antagonists has been identified, utilizing leads from high-throughput screening which were further modified based on insights from competitor molecules. Lead optimization was pursued by balancing opposing trends of metabolic stability and potency. Selective and potent analogs with good pharmacokinetic properties were successfully developed.

Related Organizations

Roche (United States)
United States
Roche (Switzerland)
Switzerland

Keywords

Receptors, CCR5, Haplorhini, Rats, Structure-Activity Relationship, Dogs, Piperidines, CCR5 Receptor Antagonists, Animals, Humans, Spiro Compounds, Caco-2 Cells

1 Research products, page 1 of 1

BindingDB Entry 50031301: Spiropiperidine CCR5 antagonists.
2010IsSourceOf

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	22
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Average
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%