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Design and synthesis of a fluorescent muscarinic antagonist

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2008 English Publisher:Elsevier BVJournal:Bioorganic & Medicinal Chemistry Letters, volume 18, pages 825-827 (issn: 0960-894X,

Authors: Carolyn Napier; J. W. Watson; Lyn H. Jones; Sasha Sreckovic; Amy Randall; Mike Trevethick;

doi: 10.1016/j.bmcl.2007.11.022

pmid: 18042383

Design and synthesis of a fluorescent muscarinic antagonist

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Abstract

The design and concise synthesis of a fluorescent tolterodine-BODIPY (boron dipyrromethene) conjugate is described which possesses potent antimuscarinic activity. This derivative illustrates proof-of-concept for the preparation of other useful fluorophoric antimuscarinic agents which have potential utility in receptor occupancy studies and high throughput screens.

Related Organizations

Pfizer (United Kingdom)
United Kingdom
Pfizer (United States)
United States

Keywords

Structure-Activity Relationship, Magnetic Resonance Spectroscopy, Chromatography, Thin Layer, Muscarinic Antagonists, Fluorescent Dyes, Half-Life

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Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	18
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%