Benzazepinone Nav1.7 blockers: Potential treatments for neuropathic pain
Copyright policy ) Scott B, Hoyt; Clare, London; Hyun, Ok; Edward, Gonzalez; Joseph L, Duffy; Catherine, Abbadie; Brian, Dean; +16 Authors
Scott B, Hoyt; Clare, London; Hyun, Ok; Edward, Gonzalez; Joseph L, Duffy; Catherine, Abbadie; Brian, Dean; John P, Felix; Maria L, Garcia; Nina, Jochnowitz; Bindhu V, Karanam; Xiaohua, Li; Kathryn A, Lyons; Erin, McGowan; D Euan, Macintyre; William J, Martin; Birgit T, Priest; McHardy M, Smith; Richard, Tschirret-Guth; Vivien A, Warren; Brande S, Williams; Gregory J, Kaczorowski; William H, Parsons;
Benzazepinone Nav1.7 blockers: Potential treatments for neuropathic pain
A series of benzazepinones were synthesized and evaluated as hNa(v)1.7 sodium channel blockers. Several compounds from this series displayed good oral bioavailability and exposure and were efficacious in a rat model of neuropathic pain.
- Merck & Co. United States
Benzodiazepinones, Molecular Structure, NAV1.7 Voltage-Gated Sodium Channel, Drug Evaluation, Preclinical, Biological Availability, Sodium Channels, Rats, Disease Models, Animal, Dogs, Animals, Neuralgia, Sodium Channel Blockers
Benzodiazepinones, Molecular Structure, NAV1.7 Voltage-Gated Sodium Channel, Drug Evaluation, Preclinical, Biological Availability, Sodium Channels, Rats, Disease Models, Animal, Dogs, Animals, Neuralgia, Sodium Channel Blockers
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selected citations
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These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
Citations provided by BIP!popularityPopularity provided by BIP!
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
Popularity provided by BIP! 47
Top 10%
Top 10%
Top 10%
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