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Mycophenolic acid as a latent agonist of PPARγ

descriptionPublicationkeyboard_double_arrow_right Article 01 Sep 2007Publisher:Elsevier BVJournal:Bioorganic & Medicinal Chemistry Letters, volume 17, pages 4,767-4,770 (issn: 0960-894X,

Authors: Mie Tsuruga; Nobuyasu Matsuura; Keiko Taki; Shinya Mitsuhashi; Hitomi Takamori; Kaoru Yamashita; Noriyuki Nakajima; +4 Authors

doi: 10.1016/j.bmcl.2007.06.059

pmid: 17618115

Mycophenolic acid as a latent agonist of PPARγ

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Abstract

Mycophenolic acid (MPA), known as an inhibitor of inosine monophosphate dehydrogenase (IMPDH), was found to inhibit the differentiation of 3T3-L1 pre-adipocytes into mature adipocytes. Although the effect of MPA was attributed to inhibition of IMPDH, we uncovered a hidden biological property of MPA as an agonist of peroxisome proliferator activated receptor gamma (PPARgamma).

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Keywords

Time Factors, Dose-Response Relationship, Drug, Chemistry, Pharmaceutical, Cell Differentiation, Mycophenolic Acid, Ligands, PPAR gamma, Mice, Structure-Activity Relationship, Models, Chemical, 3T3-L1 Cells, Cell Line, Tumor, Drug Design, Animals, Humans

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BindingDB Entry 50020794: Mycophenolic acid as a latent agonist of PPARgamma.
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