Novel tetrahydroisoquinolines are histamine H3 antagonists and serotonin reuptake inhibitors
Copyright policy )Novel tetrahydroisoquinolines are histamine H3 antagonists and serotonin reuptake inhibitors
A series of novel 4-aryl-1,2,3,4-tetrahydroisoquinoline-based histamine H(3) ligands that also have serotonin reuptake transporter inhibitor activity is described. The synthesis, in vitro biological data, and select pharmacokinetic data for these novel compounds are discussed.
- Johnson Research & Development (United States) United States
- Johnson & Johnson (United States) United States
- Johnson & Johnson Pharmaceutical Research and Development China (People's Republic of)
Models, Molecular, Serotonin Plasma Membrane Transport Proteins, Dopamine Plasma Membrane Transport Proteins, Histamine Antagonists, Molecular Conformation, Crystallography, X-Ray, Rats, Norepinephrine, Structure-Activity Relationship, Tetrahydroisoquinolines, Animals, Humans, Receptors, Histamine H3, Indicators and Reagents, Selective Serotonin Reuptake Inhibitors, Half-Life
Models, Molecular, Serotonin Plasma Membrane Transport Proteins, Dopamine Plasma Membrane Transport Proteins, Histamine Antagonists, Molecular Conformation, Crystallography, X-Ray, Rats, Norepinephrine, Structure-Activity Relationship, Tetrahydroisoquinolines, Animals, Humans, Receptors, Histamine H3, Indicators and Reagents, Selective Serotonin Reuptake Inhibitors, Half-Life
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