Novel carbazole derivatives as NPY Y1 antagonists
Copyright policy )Novel carbazole derivatives as NPY Y1 antagonists
The synthesis of a series of carbazole derivatives and their SAR at the NPY Y1 receptor is described. Modulation of physicochemical properties by appropriate decoration led to the identification of a high-affinity NPY Y1 antagonist that shows high brain penetration and modest oral bioavailability.
Male, Chemical Phenomena, Chemistry, Physical, Carbazoles, Biological Availability, Brain, CHO Cells, Rats, Receptors, Neuropeptide Y, Rats, Sprague-Dawley, Structure-Activity Relationship, Cricetulus, Cricetinae, Animals, Indicators and Reagents, Half-Life
Male, Chemical Phenomena, Chemistry, Physical, Carbazoles, Biological Availability, Brain, CHO Cells, Rats, Receptors, Neuropeptide Y, Rats, Sprague-Dawley, Structure-Activity Relationship, Cricetulus, Cricetinae, Animals, Indicators and Reagents, Half-Life
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