Simplified staurosporine analogs as potent JAK3 inhibitors
Copyright policy ) Shyh-Ming, Yang; Ravi, Malaviya; Lawrence J, Wilson; Rochelle, Argentieri; Xin, Chen; Cangming, Yang; Bingbing, Wang; +2 Authors
Shyh-Ming, Yang; Ravi, Malaviya; Lawrence J, Wilson; Rochelle, Argentieri; Xin, Chen; Cangming, Yang; Bingbing, Wang; Druie, Cavender; William V, Murray;
Simplified staurosporine analogs as potent JAK3 inhibitors
Simplification of bottom ring and regioselective functionalization of the indolocarbazole unit of staurosporine (2) are described. The modification led to a new series of simplified staurosporine analogs, which exhibited significant inhibitory activity against Janus kinase 3 (JAK3). The structure-activity relationships (SAR) are discussed and a proposed binding model is also highlighted.
- Johnson Research & Development (United States) United States
- Johnson & Johnson Pharmaceutical Research and Development China (People's Republic of)
- Johnson & Johnson (United States) United States
Models, Molecular, Structure-Activity Relationship, Adenosine Triphosphate, Janus Kinase 3, Indicators and Reagents, Enzyme Inhibitors, Staurosporine, Protein Binding
Models, Molecular, Structure-Activity Relationship, Adenosine Triphosphate, Janus Kinase 3, Indicators and Reagents, Enzyme Inhibitors, Staurosporine, Protein Binding
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This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
Popularity provided by BIP! 68
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