Xanthine mimetics as potent dipeptidyl peptidase IV inhibitors
Copyright policy )Xanthine mimetics as potent dipeptidyl peptidase IV inhibitors
A series of xanthine mimetics containing 5,5 and 5,6 heterocycle fused imidazoles were synthesized as dipeptidyl peptidase IV inhibitors. Compound 7 is potent (h-DPPIV K(i)=2nM) and exhibits excellent selectivity and no species specificity against rat and human enzymes. The X-ray structure confirms that the binding mode of 7 to rat DPPIV is similar to the parent xanthines.
- Abbott (United States) United States
Models, Molecular, Dipeptidyl-Peptidase IV Inhibitors, Protein Conformation, Dipeptidyl Peptidase 4, Imidazoles, Rats, Kinetics, Structure-Activity Relationship, X-Ray Diffraction, Xanthines, Animals, Protease Inhibitors
Models, Molecular, Dipeptidyl-Peptidase IV Inhibitors, Protein Conformation, Dipeptidyl Peptidase 4, Imidazoles, Rats, Kinetics, Structure-Activity Relationship, X-Ray Diffraction, Xanthines, Animals, Protease Inhibitors
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