Propionylpiperazines as human melanocortin-4 receptor ligands
Copyright policy ) Caroline W, Chen; Joe A, Tran; Wanlong, Jiang; Fabio C, Tucci; Melissa, Arellano; Jenny, Wen; Beth A, Fleck; +7 Authors
Caroline W, Chen; Joe A, Tran; Wanlong, Jiang; Fabio C, Tucci; Melissa, Arellano; Jenny, Wen; Beth A, Fleck; Dragan, Marinkovic; Nicole S, White; Joseph, Pontillo; John, Saunders; Ajay, Madan; Alan C, Foster; Chen, Chen;
Propionylpiperazines as human melanocortin-4 receptor ligands
A series of alpha-benzylpropionylpiperazines were synthesized and tested as antagonists of the melanocortin-4 receptor. In addition to its high potency and selectivity, R-11a had desirable pharmacokinetic properties including high brain penetration in mice.
- Neurocrine Biosciences (United States) United States
Molecular Structure, Ligands, Amides, Piperazines, Mice, Structure-Activity Relationship, Animals, Humans, Receptor, Melanocortin, Type 4, Piperazine
Molecular Structure, Ligands, Amides, Piperazines, Mice, Structure-Activity Relationship, Animals, Humans, Receptor, Melanocortin, Type 4, Piperazine
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These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
Citations provided by BIP!popularityPopularity provided by BIP!
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
Popularity provided by BIP! 12
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Top 10%
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