Aryloxyethylamines: Binding at α7 nicotinic acetylcholine receptors

descriptionPublicationkeyboard_double_arrow_right Article 01 Aug 2006 English Publisher:Elsevier BVJournal:Bioorganic & Medicinal Chemistry Letters, volume 16, pages 4,283-4,286 (issn: 0960-894X,

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Authors: Hanan M, Ragab; Jin Sung, Kim; Małgorzata, Dukat; Hernán, Navarro; Richard A, Glennon;

doi: 10.1016/j.bmcl.2006.05.080

pmid: 16765047

Aryloxyethylamines: Binding at α7 nicotinic acetylcholine receptors

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Abstract

Structure-affinity relationships for the binding of 3-[2-(N,N,N-trimethylammonium)ethoxy]pyridine (AXPQ) at alpha7 nACh receptors were investigated due to its close structural similarity to a known alpha7 antagonist.

Related Organizations

Virginia Commonwealth University
United States
RTI International
United States
Research Triangle Park Foundation
United States

Keywords

alpha7 Nicotinic Acetylcholine Receptor, Pyridines, Chemistry, Pharmaceutical, Temperature, Nicotinic Antagonists, Receptors, Nicotinic, Choline, Kinetics, Models, Chemical, Drug Design, Ethylamines, Ethers

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