Substituted coumarins as potent 5-lipoxygenase inhibitors

descriptionPublicationkeyboard_double_arrow_right Article 01 May 2006 English Publisher:Elsevier BVJournal:Bioorganic & Medicinal Chemistry Letters, volume 16, pages 2,528-2,531 (issn: 0960-894X,

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Authors: Erich L, Grimm; Christine, Brideau; Nathalie, Chauret; Chi-Chung, Chan; Daniel, Delorme; Yves, Ducharme; Diane, Ethier; +8 Authors

doi: 10.1016/j.bmcl.2006.01.085

pmid: 16464579

Substituted coumarins as potent 5-lipoxygenase inhibitors

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Abstract

Leukotriene biosynthesis inhibitors have potential as therapeutic agents for asthma and inflammatory diseases. A novel series of substituted coumarin derivatives has been synthesized and the structure-activity relationship was evaluated with respect to their ability to inhibit the formation of leukotrienes via the human 5-lipoxygenase enzyme.

Related Organizations

Merck & Co.
United States

Keywords

Structure-Activity Relationship, Molecular Structure, Coumarins, Humans, Lipoxygenase Inhibitors, Enzyme Inhibitors

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