Design and synthesis of 7H-pyrrolo[2,3-d]pyrimidines as focal adhesion kinase inhibitors. Part 1
Copyright policy )Design and synthesis of 7H-pyrrolo[2,3-d]pyrimidines as focal adhesion kinase inhibitors. Part 1
A series of 2-amino-9-aryl-7H-pyrrolo[2,3-d]pyrimidines were designed and synthesized to target focal adhesion kinase (FAK). A number of these pyrrolopyrimides exhibited low micromolar inhibitory activities against focal adhesion kinase, and their preliminary SAR was established via systematic chemical modifications. The 2-amino-9-aryl-7H-pyrrolo[2,3-d]pyrimidines represent a new class of kinase inhibitors.
- Novartis (Japan) Japan
- Novartis (United States) United States
- Novartis (Switzerland) Switzerland
- Genomics Institute of the Novartis Research Foundation United States
Structure-Activity Relationship, Pyrimidines, Cell Line, Tumor, Focal Adhesion Protein-Tyrosine Kinases, Humans, Antineoplastic Agents, Pyrroles, Drug Screening Assays, Antitumor, Enzyme Inhibitors
Structure-Activity Relationship, Pyrimidines, Cell Line, Tumor, Focal Adhesion Protein-Tyrosine Kinases, Humans, Antineoplastic Agents, Pyrroles, Drug Screening Assays, Antitumor, Enzyme Inhibitors
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