Synthesis and anticancer activity of thiosemicarbazones
Copyright policy )Synthesis and anticancer activity of thiosemicarbazones
Twenty-six thiosemicarbazones (III-1-III-26) were synthesized via three steps starting from hydrazine hydrate and carbon disulfide. The testing of anticancer activity of these compounds in vitro against P-388, A-549, and SGC-7901 shows that compounds III-15 and III-16 possess a higher inhibitory ability for P-388 and SGC-7901. Further testing shows that the value of IC50 of compound III-16 against SGC-7901 reaches to 0.032 microM.
- Zhejiang University of Technology China (People's Republic of)
- Zhejiang University of Science and Technology China (People's Republic of)
- Zhejiang Pharmaceutical College China (People's Republic of)
Thiosemicarbazones, Inhibitory Concentration 50, Structure-Activity Relationship, Hydrazines, Carbon Disulfide, Tumor Cells, Cultured, Animals, Antineoplastic Agents, Drug Screening Assays, Antitumor
Thiosemicarbazones, Inhibitory Concentration 50, Structure-Activity Relationship, Hydrazines, Carbon Disulfide, Tumor Cells, Cultured, Animals, Antineoplastic Agents, Drug Screening Assays, Antitumor
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