Factor VIIa inhibitors: Improved pharmacokinetic parameters

descriptionPublicationkeyboard_double_arrow_right Article 01 Apr 2006 English Publisher:Elsevier BVJournal:Bioorganic & Medicinal Chemistry Letters, volume 16, pages 2,243-2,246 (issn: 0960-894X,

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Authors: Aleksandr, Kolesnikov; Roopa, Rai; Wendy B, Young; Joyce, Mordenti; Liang, Liu; Steven, Torkelson; William D, Shrader; +6 Authors

doi: 10.1016/j.bmcl.2006.01.037

pmid: 16455251

Factor VIIa inhibitors: Improved pharmacokinetic parameters

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Abstract

Efforts to improve the potency and pharmacokinetic properties of small molecule factor VIIa inhibitors are described. Small structural modifications to existing leads allow the modulation of half-life and clearance, potentially making these compounds suitable candidates for drug development.

Related Organizations

CELERA CORPORATION
United States

Keywords

Serine Proteinase Inhibitors, Molecular Structure, Anticoagulants, Factor VIIa, Structure-Activity Relationship, Drug Design, Animals, Humans, Blood Coagulation, Half-Life

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