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image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Bioorganic & Medicin...arrow_drop_down
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Bioorganic & Medicinal Chemistry Letters
Article . 2005 . Peer-reviewed
License: Elsevier TDM
Data sources: Crossref
image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
Archivio Istituzionale della Ricerca - Università degli Studi della Campania "Luigi Vanvitelli"
Article . 2005
Data sources: Archivio Istituzionale della Ricerca - Università degli Studi della Campania "Luigi Vanvitelli"
Bioorganic & Medicinal Chemistry Letters
Article . 2005
Data sources: Europe PubMed Central
https://dx.doi.org/10.1016/j.b...
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Non-competitive inhibitors of metabotropic glutamate receptor 5 (mGluR5)

descriptionPublicationkeyboard_double_arrow_right Article 01 Jun 2005 Italy English Publisher:Elsevier BVJournal:Bioorganic & Medicinal Chemistry Letters, volume 15, pages 2,876-2,880 (issn: 0960-894X, Copyright policy )
Authors: Tasler S; Kraus M; Pegoraro S; Aschenbrenner A; Poggesi E; Testa R; MOTTA, Gaetano; +1 Authors

doi: 10.1016/j.bmcl.2005.03.089

pmid: 15878659

handle: 11591/166027

Non-competitive inhibitors of metabotropic glutamate receptor 5 (mGluR5)

Abstract

Based on a pharmacophore alignment on known non-competitive mGluR5 inhibitors applying 4SCan technology, a new lead series was identified and further structurally investigated. K(i)'s as low as around 100 nM were achieved.

Country
Italy
Related Organizations
Keywords

Structure-Activity Relationship, Receptor, Metabotropic Glutamate 5, Receptors, Metabotropic Glutamate, Excitatory Amino Acid Antagonists

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    popularity
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    influence
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
5
Average
Average
Average
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