3,3-Bisaryloxindoles as mineralocorticoid receptor antagonists

descriptionPublicationkeyboard_double_arrow_right Article 01 May 2005 English Publisher:Elsevier BVJournal:Bioorganic & Medicinal Chemistry Letters, volume 15, pages 2,553-2,557 (issn: 0960-894X,

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Authors: David A, Neel; Matthew L, Brown; Peter A, Lander; Timothy A, Grese; Jean M, Defauw; Robert A, Doti; Todd, Fields; +5 Authors

doi: 10.1016/j.bmcl.2005.03.086

pmid: 15863315

3,3-Bisaryloxindoles as mineralocorticoid receptor antagonists

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Abstract

Syntheses and SAR studies of 3,3-bisaryloxindole analogues provided potent mineralocorticoid receptor (MR) antagonists that were selective over other steroid nuclear hormone receptors.

Related Organizations

Eli Lilly (United States)
United States

Keywords

Radioligand Assay, Indoles, Humans, Mineralocorticoid Receptor Antagonists

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