Cyclic dipeptides exhibit potency for scavenging radicals

descriptionPublicationkeyboard_double_arrow_right Article 01 Mar 2012 English Publisher:Elsevier BVJournal:Bioorganic & Medicinal Chemistry, volume 20, pages 2,002-2,009 (issn: 0968-0896,

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Authors: Tadashi, Furukawa; Takashi, Akutagawa; Hitomi, Funatani; Toshikazu, Uchida; Yoshihiro, Hotta; Masatake, Niwa; Yoshiaki, Takaya;

doi: 10.1016/j.bmc.2012.01.050

pmid: 22356736

Cyclic dipeptides exhibit potency for scavenging radicals

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Abstract

Twenty kinds of cyclic dipeptides containing l-leucine were synthesized, and their antioxidant activity against ·OH and O(2)(·-) was investigated. Compounds possessing polar amino acid residues, such as Asp, Cys, Glu, Lys, Pro, Ser, and Trp, exhibited higher antioxidant activity against ·OH than vitamin E. However, only cyclo(l-Cys-l-Leu) scavenged O(2)(·-).

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Keywords

Singlet Oxygen, Hydroxyl Radical, Leucine, Amino Acid Sequence, Dipeptides, Free Radical Scavengers, Peptides, Cyclic

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