Structures of new amphidinols with truncated polyhydroxyl chain and their membrane-permeabilizing activities
Copyright policy )Structures of new amphidinols with truncated polyhydroxyl chain and their membrane-permeabilizing activities
Two new homologues of amphidinols (AM14 and AM15) were isolated from the cultured dinoflagellate Amphidinium klebsii. The structures were elucidated on the basis of 2D NMR and collision-induced dissociation MS/MS and turned out to be closely related homologues of AM7. Their weak membrane-disrupting activity indicates that the hydrophobic polyene chain is essential for the potent biological activities. Structure-activity relationship for the polyhydroxyl part was then examined with use of AM homologues possessing various chain lengths, indicating that the pore size of the channel/lesion formed by AMs was not greatly affected by the length of the polyhydroxyl chain.
- Osaka University Japan
Spectrometry, Mass, Electrospray Ionization, Antifungal Agents, Cell Membrane Permeability, Erythrocytes, Magnetic Resonance Spectroscopy, Chemical Phenomena, Chemistry, Physical, Fungi, Microbial Sensitivity Tests, Alkenes, In Vitro Techniques, Hemolysis, Mass Spectrometry, Structure-Activity Relationship, Aspergillus, Dinoflagellida, Animals, Humans, Spectrophotometry, Ultraviolet, Pyrans
Spectrometry, Mass, Electrospray Ionization, Antifungal Agents, Cell Membrane Permeability, Erythrocytes, Magnetic Resonance Spectroscopy, Chemical Phenomena, Chemistry, Physical, Fungi, Microbial Sensitivity Tests, Alkenes, In Vitro Techniques, Hemolysis, Mass Spectrometry, Structure-Activity Relationship, Aspergillus, Dinoflagellida, Animals, Humans, Spectrophotometry, Ultraviolet, Pyrans
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