Anticancer activities of novel chalcone and bis-chalcone derivatives
Copyright policy )Anticancer activities of novel chalcone and bis-chalcone derivatives
A series of novel chalcones and bis-chalcones containing boronic acid moieties has been synthesized and evaluated for antitumor activity against the human breast cancer MDA-MB-231 (estrogen receptor-negative) and MCF7 (estrogen receptor-positive) cell lines and against two normal breast epithelial cell lines, MCF-10A and MCF-12A. These molecules inhibited the growth of the human breast cancer cell lines at low micromolar to nanomolar concentrations, with five of them (1-4, 9) showing preferential inhibition of the human breast cancer cell lines. Furthermore, bis-chalcone 8 exhibited a more potent inhibition of colon cancer cells expressing wild-type p53 than of an isogenic cell line that was p53-null.
- Johns Hopkins University United States
- The University of Texas MD Anderson Cancer Center United States
- Johns Hopkins Medicine United States
- JOHNS HOPKINS UNIVERSITY United States
- Sidney Kimmel Comprehensive Cancer Center United States
Dose-Response Relationship, Drug, Molecular Structure, Antineoplastic Agents, Breast Neoplasms, Boronic Acids, Lethal Dose 50, Chalones, Piperidines, Cell Line, Tumor, Colonic Neoplasms, Humans, Female, Drug Screening Assays, Antitumor
Dose-Response Relationship, Drug, Molecular Structure, Antineoplastic Agents, Breast Neoplasms, Boronic Acids, Lethal Dose 50, Chalones, Piperidines, Cell Line, Tumor, Colonic Neoplasms, Humans, Female, Drug Screening Assays, Antitumor
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