4-Aminoquinoline quinolizidinyl- and quinolizidinylalkyl-derivatives with antimalarial activity
Copyright policy )4-Aminoquinoline quinolizidinyl- and quinolizidinylalkyl-derivatives with antimalarial activity
A set of quinolizidinyl and quinolizidinylalkyl derivatives of 4-amino-7-chloroquinoline and of 9-amino-6-chloro-2-methoxyacridine were prepared and tested in vitro against CQ-sensitive (D-10) and CQ-resistant (W-2) strains of Plasmodium falciparum. All compounds but one exerted significant antimalarial activity. Some of the quinolizidine derivatives were from 5 to 10 times more active than chloroquine on the CQ-resistant strain. No toxicity against mammalian cells was observed.
- University of Genoa Italy
- University of Milan Italy
4-Aminoquinoline derivatives; Antimalarial agents; Chloroquine; P. falciparum; Quinolizidine derivatives, Plasmodium berghei, Plasmodium falciparum, Chloroquine, Plasmodium yoelii, Cell Line, Antimalarials, Mice, Parasitic Sensitivity Tests, Aminoquinolines, Animals, Quinolizines
4-Aminoquinoline derivatives; Antimalarial agents; Chloroquine; P. falciparum; Quinolizidine derivatives, Plasmodium berghei, Plasmodium falciparum, Chloroquine, Plasmodium yoelii, Cell Line, Antimalarials, Mice, Parasitic Sensitivity Tests, Aminoquinolines, Animals, Quinolizines
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