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Discovery of novel modulators of metabotropic glutamate receptor subtype-5

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2004Publisher:Elsevier BVJournal:Bioorganic & Medicinal Chemistry, volume 12, pages 17-21 (issn: 0968-0896,

Authors: Bowei Wang; Janice Chung; Jeffery J. Anderson; Jean Michel Vernier; Benito Munoz; Jesse Brodkin; Michael F. Gardner; +3 Authors

doi: 10.1016/j.bmc.2003.10.021

pmid: 14697765

Discovery of novel modulators of metabotropic glutamate receptor subtype-5

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Abstract

A series of potent and selective mGluR5 antagonists were synthesized and evaluated in vitro and in vivo. It was found that a pyridyl functionality is a potential replacement for acetonitrile in the lead structure, with 2-pyridyl being most favored. Additionally, the benzoxazole moiety could also be replaced by other heterobicyclic rings such as imidazothiazole.

Related Organizations

General Atomics (United States)
United States

Keywords

Benzoxazoles, Receptor, Metabotropic Glutamate 5, Animals, Biological Availability, Receptors, Metabotropic Glutamate, Excitatory Amino Acid Antagonists, Rats

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	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	35
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	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%