Approval of oliceridine (TRV130) for intravenous use in moderate to severe pain in adults
Copyright policy )Approval of oliceridine (TRV130) for intravenous use in moderate to severe pain in adults
EditordOpioids used for the treatment of moderate to severe pain in an appropriate setting with appropriate management (stewardship) have good efficacy. However, when these are used long term their efficacy is questionable. Tolerance develops leading to escalating doses and a vicious circle of side-effects. These side-effects include respiratory depression and immune suppression; both are relevant in the coronavirus disease 2019 (COVID-19) pandemic. Design and evaluation of analgesics with reduced side-effect profiles is an important goal; where these side-effects include addiction, this approach can also address the opioid crisis.
- University of Ferrara Italy
- University of Padua Italy
- University of Leicester United Kingdom
biased agonist; mu opioid receptor; oliceridine; opioid; partial agonist; side-effects; TRV130, Correspondence, Injections, Intravenous, biased agonist, mu opioid receptor, oliceridine, opioid, partial agonist, side-effects, TRV130, Humans, Pain, Spiro Compounds, Thiophenes, Drug Approval
biased agonist; mu opioid receptor; oliceridine; opioid; partial agonist; side-effects; TRV130, Correspondence, Injections, Intravenous, biased agonist, mu opioid receptor, oliceridine, opioid, partial agonist, side-effects, TRV130, Humans, Pain, Spiro Compounds, Thiophenes, Drug Approval
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).38 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!