CD98 signals controlling tumorigenesis

descriptionPublicationkeyboard_double_arrow_right Article 01 Dec 2016 English Publisher:Elsevier BVJournal:The International Journal of Biochemistry & Cell Biology, volume 81, pages 148-150 (issn: 1357-2725,

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Authors: Hugh, Ip; Tariq, Sethi;

doi: 10.1016/j.biocel.2016.11.005

pmid: 27840151

CD98 signals controlling tumorigenesis

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Abstract

CD98 is implicated in a large number of cancers. CD98 regulates amino acid transport and integrin signaling, which are key drivers in tumor progression. The light chain in the CD98 heterodimer functions as an amino acid exchanger. Alongside the light chain, the heavy chain forms a heterocomplex at the plasma membrane to mediate signaling pathways. In this article, we review various approaches to blocking CD98 activity, which may lead to novel opportunities in cancer therapeutics.

Related Organizations

ASTRAZENECA UK LIMITED
United Kingdom
AstraZeneca (United Kingdom)
United Kingdom
Guy's and St Thomas' NHS Foundation Trust
United Kingdom

Keywords

Carcinogenesis, Animals, Humans, Fusion Regulatory Protein-1, Signal Transduction

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