CCL2 DNA vaccine to treat renal disease

descriptionPublicationkeyboard_double_arrow_right Article 01 Apr 2009 Australia English Publisher:Elsevier BVJournal:The International Journal of Biochemistry & Cell Biology, volume 41, pages 729-732 (issn: 1357-2725,

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Authors: Watson, Debbie; Zheng, Guoping; Wu, Huiling; Wang, Yuan Min; Wang, Yiping; Harris, David C. H; Alexander, S I;

doi: 10.1016/j.biocel.2008.04.028

pmid: 18768165

CCL2 DNA vaccine to treat renal disease

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Abstract

CCL2 DNA vaccines are directed against the host chemoattractant molecule CCL2 (MCP-1), a key chemokine in recruiting macrophages to sites of inflammation. Macrophages recruited by CCL2 lead to progressive renal injury. In rat models of disease unmodified CCL2 DNA vaccine in combination with a CCL5 (RANTES) DNA vaccine can protect against chronic renal disease. The mechanism of protection involves the induction of auto-antibodies to the CCL2. Introduction of the adjuvant p-tet into the DNA structure of the CCL2 vaccine leads to enhanced potency with the induction of specific Th1 cellular immunity. The strategies outlined here demonstrate a model for developing potent vaccines against highly restricted self targets.

Country

Australia

Related Organizations

University of Wollongong
Australia
Royal Prince Alfred Hospital
Australia
Children's Hospital at Westmead
Australia
University of Sydney
Australia

Keywords

DNA vaccine, Monocyte chemoattractant protein 1, Molecular Sequence Data, Adriamycin nephropathy, Social and Behavioral Sciences, Rats, Disease Models, Animal, Chemokine, Medicine and Health Sciences, Vaccines, DNA, Animals, Humans, CMMB, Kidney Diseases, Amino Acid Sequence, Immune response, Chemokine CCL2

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