The soluble transforming growth factor-β receptor: Advantages and applications
Copyright policy )The soluble transforming growth factor-β receptor: Advantages and applications
Transforming growth factor-beta (TGF-beta) is a cytokine that plays a pivotal role in growth, differentiation, development, immune response and wound healing. TGF-beta is upregulated following wound infliction and inflammation, and plays an important role in the production of extracellular matrix proteins that contribute to tissue repair. However, in some diseases, TGF-beta dysregulation can lead to tumor formation, organ fibrosis and the disruption of organ function. A number of molecules have been designed to counteract the effects of TGF-beta, including anti-TGF-beta monoclonal antibodies and various small molecules. Here we discuss the design, use and advantages of the highly specific TGF-beta binding molecule, the soluble human TGF-beta receptor (sTbetaR.Fc) as a TGF-beta sequestering agent.
- Harvard University United States
- Center for Systems Biology United States
Wound Healing, Receptors, IgG, Antibodies, Monoclonal, Cell Differentiation, Fibrosis, Immunity, Innate, Recombinant Proteins, Extracellular Matrix, Transforming Growth Factor beta, Neoplasms, Animals, Humans, Immunotherapy, Cell Proliferation, Signal Transduction
Wound Healing, Receptors, IgG, Antibodies, Monoclonal, Cell Differentiation, Fibrosis, Immunity, Innate, Recombinant Proteins, Extracellular Matrix, Transforming Growth Factor beta, Neoplasms, Animals, Humans, Immunotherapy, Cell Proliferation, Signal Transduction
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