Aurora kinases

descriptionPublicationkeyboard_double_arrow_right Article 01 Aug 2005 English Publisher:Elsevier BVJournal:The International Journal of Biochemistry & Cell Biology, volume 37, pages 1,572-1,577 (issn: 1357-2725,

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Authors: Victor M, Bolanos-Garcia;

doi: 10.1016/j.biocel.2005.02.021

pmid: 15896667

Aurora kinases

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Abstract

Aurora kinases A (also known as Aurora, Aurora-2, AIK, AIR-1, AIRK1, AYK1, BTAK, Eg2, MmIAK1 and STK15), Aurora B (also known as Aurora-1, AIM-1, AIK2, AIR-2, AIRK-2, ARK2, IAL-1 and STK12) and Aurora C (also known as AIK3) participate in several biological processes, including cytokinesis and dysregulated chromosome segregation. These important regulators of mitosis are over-expressed in diverse solid tumors. One member of this family of serine-threonine kinases, human Aurora A, has been proposed as a drugable target in pancreatic cancer. The recent determination of the three-dimensional structure of Aurora A has shown that Aurora kinases exhibit unique conformations around the activation loop region. This property has boosted the search and development of inhibitors of Aurora kinases, which might also function as novel antioncogenic agents.

Related Organizations

University of Cambridge
United Kingdom

Keywords

Models, Molecular, Sequence Homology, Amino Acid, Molecular Sequence Data, Protein Serine-Threonine Kinases, Aurora Kinases, Animals, Aurora Kinase B, Humans, Aurora Kinase C, Amino Acid Sequence, Aurora Kinase A

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