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Erythroid development in the mammalian embryo

descriptionPublicationkeyboard_double_arrow_right Article 01 Dec 2013Publisher:Elsevier BVJournal:Blood Cells, Molecules, and Diseases, volume 51, pages 213-219 (issn: 1079-9796,

Authors: Johnathan L. Nieves; Andrei M. Vacaru; Margaret H. Baron;

doi: 10.1016/j.bcmd.2013.07.006

pmid: 23932234

pmc: PMC3812334

Erythroid development in the mammalian embryo

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Abstract

Erythropoiesis is the process by which progenitors for red blood cells are produced and terminally differentiate. In all vertebrates, two morphologically distinct erythroid lineages (primitive, embryonic, and definitive, fetal/adult) form successively within the yolk sac, fetal liver, and marrow and are essential for normal development. Red blood cells have evolved highly specialized functions in oxygen transport, defense against oxidation, and vascular remodeling. Here we review key features of the ontogeny of red blood cell development in mammals, highlight similarities and differences revealed by genetic and gene expression profiling studies, and discuss methods for identifying erythroid cells at different stages of development and differentiation.

Related Organizations

Icahn School of Medicine at Mount Sinai
United States
Tisch Cancer Institute
United States

Keywords

Transcription, Genetic, Gene Expression Regulation, Developmental, Cell Differentiation, Embryo, Mammalian, Erythroid Cells, Liver, Animals, Humans, Cell Lineage, Erythropoiesis, Yolk Sac

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	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	40
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	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%