Thrombophilic polymorphisms in preterm delivery

descriptionPublicationkeyboard_double_arrow_right Article 01 Jul 2004 English Publisher:Elsevier BVJournal:Blood Cells, Molecules, and Diseases, volume 33, pages 51-56 (issn: 1079-9796,

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Authors: Laura L, Valdez; Antonio, Quintero; Ernesto, Garcia; Norma, Olivares; Alfredo, Celis; Fernando, Rivas; Fernando, Rivas;

doi: 10.1016/j.bcmd.2004.04.011

pmid: 15223011

Thrombophilic polymorphisms in preterm delivery

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Abstract

Single nucleotide polymorphisms tumor necrosis factor (TNF) G-308A, coagulation factors V G1691A and II G20210A, methylenetetrahydrofolate reductase (MTHFR) C677T, as well as the angiotensin-converting enzyme (ACE) insertion/deletion polymorphism were investigated in 86 women with a history of premature delivery (PD) and compared with those of a control group of adults from Guadalajara, Mexico (a minimum of 162 individuals were typed for each polymorphism). Significant differences in the frequency of these polymorphisms were found for MTHFR C677T (increased), and the ACE deletion (increased) among women who had a history of preterm delivery compared with controls. These polymorphisms therefore might be associated with PD.

Related Organizations

University of Guadalajara
Mexico
University of Colima
Mexico
Mexican Social Security Institute
Mexico

Keywords

Adult, Polymorphism, Genetic, Adolescent, Tumor Necrosis Factor-alpha, Pregnancy Complications, Hematologic, Factor V, Peptidyl-Dipeptidase A, Polymorphism, Single Nucleotide, Pregnancy, Case-Control Studies, Humans, Premature Birth, Thrombophilia, Female, Prothrombin, Mexico, Methylenetetrahydrofolate Reductase (NADPH2), Sequence Deletion

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