Long noncoding RNA HOTTIP cooperates with CCCTC-binding factor to coordinate HOXA gene expression
Copyright policy )Long noncoding RNA HOTTIP cooperates with CCCTC-binding factor to coordinate HOXA gene expression
The spatiotemporal control of HOX gene expression is dependent on positional identity and often correlated to their genomic location within each loci. Maintenance of HOX expression patterns is under complex transcriptional and epigenetic regulation, which is not well understood. Here we demonstrate that HOTTIP, a lincRNA transcribed from the 5' edge of the HOXA locus, physically associates with the CCCTC-binding factor (CTCF) that serves as an insulator by organizing HOXA cluster into disjoint domains, to cooperatively maintain the chromatin modifications of HOXA genes and thus coordinate the transcriptional activation of distal HOXA genes in human foreskin fibroblasts. Our results reveal the functional connection of HOTTIP and CTCF, and shed light on lincRNAs in gene activation and CTCF mediated chromatin organization.
- Kunming University of Science and Technology China (People's Republic of)
- Yunnan Agricultural University China (People's Republic of)
Homeodomain Proteins, Male, CCCTC-Binding Factor, Binding Sites, Transcription, Genetic, Foreskin, Fibroblasts, Chromatin, Cell Line, Epigenesis, Genetic, Histones, Humans, Protein Isoforms, RNA, Long Noncoding, Homeobox A1 Protein, Protein Binding, Transcription Factors
Homeodomain Proteins, Male, CCCTC-Binding Factor, Binding Sites, Transcription, Genetic, Foreskin, Fibroblasts, Chromatin, Cell Line, Epigenesis, Genetic, Histones, Humans, Protein Isoforms, RNA, Long Noncoding, Homeobox A1 Protein, Protein Binding, Transcription Factors
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).22 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!