Mitochondrial dynamics coordinate cell differentiation
Copyright policy )Mitochondrial dynamics coordinate cell differentiation
Cells differentiate into specific and functional lineages to build up tissues. It has been shown in several tissues that mitochondrial morphology, levels of "mitochondria-shaping" proteins, and mitochondrial functions change upon differentiation. In this review, we highlight the significance of mitochondrial dynamics and functions in tissue development, cell differentiation, and reprogramming processes. Signalling cascades are critical for tissue stem cell maintenance and cell fate determination, and growing evidence demonstrates mitochondria could act as a centre of intra and extracellular signals to coordinate signalling pathways, such as Notch, Wnt, and YAP/TAZ signalling. Just an organelle, however, emerges as a master regulator of cell differentiation, and can be a target to manipulate cell fates.
- University of Padua Italy
- Kanazawa University Japan
Receptors, Notch, Stem Cells, Intracellular Signaling Peptides and Proteins, Gene Expression Regulation, Developmental, Cell Differentiation, YAP-Signaling Proteins, Cell Dedifferentiation, Phosphoproteins, Mitochondrial Dynamics, Mitochondria, Wnt Proteins, Transcriptional Coactivator with PDZ-Binding Motif Proteins, Trans-Activators, Animals, Humans, Cell Lineage, Adaptor Proteins, Signal Transducing, Signal Transduction, Transcription Factors
Receptors, Notch, Stem Cells, Intracellular Signaling Peptides and Proteins, Gene Expression Regulation, Developmental, Cell Differentiation, YAP-Signaling Proteins, Cell Dedifferentiation, Phosphoproteins, Mitochondrial Dynamics, Mitochondria, Wnt Proteins, Transcriptional Coactivator with PDZ-Binding Motif Proteins, Trans-Activators, Animals, Humans, Cell Lineage, Adaptor Proteins, Signal Transducing, Signal Transduction, Transcription Factors
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