Defective GATA-3 expression in Th2 LCR-deficient mice
Copyright policy )Defective GATA-3 expression in Th2 LCR-deficient mice
Th2 cell differentiation is critically influenced by transcription factor GATA-3 and by various cis-acting elements including enhancers, silencers and a locus control region (LCR) in the Th2 cytokine locus. Th2 LCR-deficient Th2 cells completely lost the expression of GATA-3 and the phosphorylation of STAT6. Histone 3 lysine 4 (H3-K4) was hypomethylated in the gata3 locus in these cells. GATA-3 and STAT6 bound several regulatory regions in the gata3 locus and transactivated the expression of the gata3 gene. These results suggest that Th2 differentiation program stimulates feed-forward regulation of gata3 gene expression.
- Sogang University Korea (Republic of)
Transcriptional Activation, Mice, Th2 Cells, Animals, Cell Differentiation, GATA3 Transcription Factor, Phosphorylation, Locus Control Region, STAT6 Transcription Factor, Mice, Mutant Strains
Transcriptional Activation, Mice, Th2 Cells, Animals, Cell Differentiation, GATA3 Transcription Factor, Phosphorylation, Locus Control Region, STAT6 Transcription Factor, Mice, Mutant Strains
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