Cathepsin D: A cellular roadmap

descriptionPublicationkeyboard_double_arrow_right Article 01 Nov 2008 English Publisher:Elsevier BVJournal:Biochemical and Biophysical Research Communications, volume 376, pages 5-9 (issn: 0006-291X,

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Authors: Nousheen, Zaidi; Andreas, Maurer; Sebastian, Nieke; Hubert, Kalbacher;

doi: 10.1016/j.bbrc.2008.08.099

pmid: 18762174

Cathepsin D: A cellular roadmap

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Abstract

Cathepsin D is a normal and major component of lysosomes, it is found in almost all cells and tissues of mammals. Present review describes different events in cellular life of cathepsin D mainly its biosynthesis, co-translational and posttranslational modifications, targeting to lysosomes and proteolytic processing and maturation within lysosomes.

Related Organizations

University of Tübingen
Germany

Keywords

Protein Transport, Transcription, Genetic, Neoplasms, Protein Biosynthesis, Animals, Humans, Lysosomes, Cathepsin D, Protein Processing, Post-Translational

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