Induced expression of the transcription of tropomodulin 1 by Wnt5a and characterization of the tropomodulin 1 promoter
Copyright policy )Induced expression of the transcription of tropomodulin 1 by Wnt5a and characterization of the tropomodulin 1 promoter
Microarray analysis was carried out to identify novel downstream target genes regulated by non-canonical Wnt signaling. We found that Tmod1, known as an actin-capping protein, is up-regulated by Wnt5a, while gelsolin, known as an actin-severing protein, is down-regulated by Wnt5a. As expected from the roles of genes regulated by Wnt5a, L929 cells expressing Wnt5a show abnormal cell shape and a reduced migration rate. Cloning and analysis of the putative promoter show that two conserved sequences, one in the 5'-end of the first exon and the other in the intron next to the first exon, are necessary for the basal promoter activity.
- Seoul National University Korea (Republic of)
- University of Seoul Korea (Republic of)
Microscopy, Confocal, Transcription, Genetic, Reverse Transcriptase Polymerase Chain Reaction, Recombinant Fusion Proteins, Green Fluorescent Proteins, Exons, Fibroblasts, Regulatory Sequences, Nucleic Acid, Transfection, Cell Line, Mice, Gene Expression Regulation, Cell Movement, Animals, Cloning, Molecular, Luciferases, Promoter Regions, Genetic, Cell Shape, Gelsolin, Oligonucleotide Array Sequence Analysis
Microscopy, Confocal, Transcription, Genetic, Reverse Transcriptase Polymerase Chain Reaction, Recombinant Fusion Proteins, Green Fluorescent Proteins, Exons, Fibroblasts, Regulatory Sequences, Nucleic Acid, Transfection, Cell Line, Mice, Gene Expression Regulation, Cell Movement, Animals, Cloning, Molecular, Luciferases, Promoter Regions, Genetic, Cell Shape, Gelsolin, Oligonucleotide Array Sequence Analysis
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