<script type="text/javascript">
<!--
document.write('<div id="oa_widget"></div>');
document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=undefined&type=result"></script>');
-->
</script>

COPY SCRIPT

For further information contact us at helpdesk@openaire.eu

esiRNA to eri-1 and adar-1 genes improving high doses of c-myc-directed esiRNA effect on mouse melanoma growth inhibition

descriptionPublicationkeyboard_double_arrow_right Article 01 Sep 2007Publisher:Elsevier BVJournal:Biochemical and Biophysical Research Communications, volume 361, pages 373-378 (issn: 0006-291X,

Authors: Yinchun Zhao; Jie Hong; Weida Huang; Zhengwu Li;

doi: 10.1016/j.bbrc.2007.07.003

pmid: 17658462

esiRNA to eri-1 and adar-1 genes improving high doses of c-myc-directed esiRNA effect on mouse melanoma growth inhibition

- Summary
- Subjects
- Related research
  (3)
- Metrics

Abstract

Knockdown of c-myc expression via RNAi is expected to be an efficient approach to suppress tumor growth. In our preliminary study, we intraperitoneally injected different doses of c-myc-directed esiRNA (esic-MYC, c-myc-directed Escherichia coli expressed and enzyme digested siRNA) into C57BL6/6J mice with bearing B16 melanoma to investigate the inhibitory effect of esic-MYC on tumor growth. However, in high dose esic-MYC treatment groups, the tumor growth inhibition was less efficient than that of low dose treatment groups. Considering the negative regulation roles of eri-1 and adar-1 genes in RNA interference, we downregulated either/both of the two genes with c-myc gene by RNAi. Our results showed esiMERI-1 (esiRNA of mouse eri-1 gene) and esiMADAR-1 (esiRNA of mouse adar-1 gene) could rescue the tumor growth suppression in the high dose esic-MYC treatment groups obviously. The data strongly suggest that silencing of eri-1 and adar-1 homologs of human being should be concerned for cancer therapy by RNAi approach.

Related Organizations

Fudan University
China (People's Republic of)

Keywords

Exonucleases, Adenosine Deaminase, Melanoma, Experimental, RNA-Binding Proteins, Apoptosis, Gene Expression Regulation, Neoplastic, Proto-Oncogene Proteins c-myc, Mice, Exoribonucleases, In Situ Nick-End Labeling, Animals, RNA Interference, RNA, Messenger, RNA, Small Interfering, Cell Proliferation

3 Research products, page 1 of 1

Hyperediting of human T-cell leukemia virus type 2 and simian T-cell leukemia virus type 3 by the dsRNA adenosine deaminase ADAR-1
2012IsAmongTopNSimilarDocuments
The "Janus-like" RNA-editing machinery in innate antiviral immunity.
IsAmongTopNSimilarDocuments
Double-Stranded RNA Adenosine Deaminase ADAR-1-Induced Hypermutated Genomes among Inactivated Seasonal Influenza and Live Attenuated Measles Virus Vaccines
2011IsAmongTopNSimilarDocuments

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	6
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Average
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average