Modification of Msx1 by SUMO-1
Copyright policy )Modification of Msx1 by SUMO-1
The small ubiquitin-related modifier SUMO reversibly modifies many proteins, including promoter-specific transcription factors. Genetic studies in both humans and mice indicate that the Msx1 transcription factor is associated with specific disorders, including cleft palate. We show that Msx1 conjugation to SUMO-1 in vivo is enhanced by an E3 SUMO ligase, PIAS1, suggesting that sumoylation of Msx1 is a new mechanism for modulating the molecular function of Msx1 during organogenesis.
- Harvard University United States
MSX1 Transcription Factor, Mice, Mice, Inbred C3H, Binding Sites, Organogenesis, SUMO-1 Protein, Animals, Cells, Cultured, Protein Binding
MSX1 Transcription Factor, Mice, Mice, Inbred C3H, Binding Sites, Organogenesis, SUMO-1 Protein, Animals, Cells, Cultured, Protein Binding
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).26 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!