Impaired bone anabolic response to parathyroid hormone in Fgf2−/− and Fgf2+/− mice
Copyright policy )Impaired bone anabolic response to parathyroid hormone in Fgf2−/− and Fgf2+/− mice
Since parathyroid hormone (PTH) increased FGF2 mRNA and protein expression in osteoblasts, and serum FGF-2 was increased in osteoporotic patients treated with PTH, we assessed whether the anabolic effect of PTH was impaired in Fgf2-/- mice. Eight-week-old Fgf2+/+ and Fgf2-/- male mice were treated with rhPTH 1-34 (80mug/kg) for 4 weeks. Micro-CT and histomorphometry demonstrated that PTH significantly increased parameters of bone formation in femurs from Fgf2+/+ mice but the changes were smaller and not significant in Fgf2-/- mice. IGF-1 was significantly reduced in serum from PTH-treated Fgf2-/- mice. DEXA analysis of femurs from Fgf2+/+, Fgf2+/-, and Fgf2-/- mice treated with rhPTH (160mug/kg) for 10 days showed that PTH significantly increased femoral BMD in Fgf2+/+ by 18%; by only 3% in Fgf2+/- mice and reduced by 3% in Fgf2-/- mice. We conclude that endogenous Fgf2 is important for maximum bone anabolic effect of PTH in mice.
- University System of Ohio United States
- University of Montana United States
- Jackson Laboratory United States
- University of Nagasaki Japan
- University of Connecticut Health Center United States
Male, Recombinant-Proteins, 610, Bone and Bones, H, Mice, Receptor-Fibroblast-Growth-Factor-Type-2, Bone Density, Osteogenesis, Teriparatide, Animals, Humans, Femur, Research-Support-N, Receptor, Fibroblast Growth Factor, Type 2, -Extramural, Tomography-X-Ray-Computed, Mice, Knockout, Mice-Knockout, I, Recombinant Proteins, Parathyroid Hormone, Parathyroid-Hormone, Female, Tomography, X-Ray Computed, Bone-and-Bones
Male, Recombinant-Proteins, 610, Bone and Bones, H, Mice, Receptor-Fibroblast-Growth-Factor-Type-2, Bone Density, Osteogenesis, Teriparatide, Animals, Humans, Femur, Research-Support-N, Receptor, Fibroblast Growth Factor, Type 2, -Extramural, Tomography-X-Ray-Computed, Mice, Knockout, Mice-Knockout, I, Recombinant Proteins, Parathyroid Hormone, Parathyroid-Hormone, Female, Tomography, X-Ray Computed, Bone-and-Bones
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