The fission yeast ptr1+ gene involved in nuclear mRNA export encodes a putative ubiquitin ligase
Copyright policy )The fission yeast ptr1+ gene involved in nuclear mRNA export encodes a putative ubiquitin ligase
Fission yeast ptr1-1 is one of the mRNA transport mutants that accumulate poly(A)+ RNA in the nuclei at the nonpermissive temperature. We found that the ptr1+ gene encodes a homolog of Saccharomyces cerevisiae Tom1p, a hect type ubiquitin ligase. In ptr1-1, a conserved amino acid in the hect domain of Ptr1p is mutated. The ptr1+ gene is essential for growth and its mutation did not affect nuclear protein export. A ptr1-1 rae1-167 double mutant showed a synthetic effect on a growth defect, indicating that Ptr1p functionally interacts with an essential mRNA export factor Rae1p. We also isolated a multi-copy suppressor for ptr1-1 and found that it is the mpd2+ gene isolated as a multi-copy suppressor of cdc7-PD1.
- Kyushu University Japan
- Kumamoto University Japan
Cell Nucleus, Homeodomain Proteins, Saccharomyces cerevisiae Proteins, Sequence Homology, Amino Acid, Ubiquitin-Protein Ligases, Molecular Sequence Data, Active Transport, Cell Nucleus, Saccharomyces cerevisiae, Cosmids, Diploidy, Recombinant Proteins, Protein Structure, Tertiary, Mutation, Schizosaccharomyces, Amino Acid Sequence, RNA, Messenger, Schizosaccharomyces pombe Proteins, Cloning, Molecular, Genes, Suppressor
Cell Nucleus, Homeodomain Proteins, Saccharomyces cerevisiae Proteins, Sequence Homology, Amino Acid, Ubiquitin-Protein Ligases, Molecular Sequence Data, Active Transport, Cell Nucleus, Saccharomyces cerevisiae, Cosmids, Diploidy, Recombinant Proteins, Protein Structure, Tertiary, Mutation, Schizosaccharomyces, Amino Acid Sequence, RNA, Messenger, Schizosaccharomyces pombe Proteins, Cloning, Molecular, Genes, Suppressor
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