Transcriptional activation of mouse mast cell protease-9 by microphthalmia-associated transcription factor
Copyright policy )Transcriptional activation of mouse mast cell protease-9 by microphthalmia-associated transcription factor
We explored transcriptional regulation of mouse mast cell protease-9 (mMCP-9), which is implicated in inflammation of the jejunum during helminth infections and tissue remodeling of the uterus during pregnancy. Transcription was positively regulated by microphthalmia-associated transcription factor (MITF), a member of the basic helix-loop-helix-leucine zipper family that binds to the E-box, a CANNTG sequence. The most significant segment for positive regulation by MITF was nt -183 to -177 of the mMCP-9 promoter, CATCATG, which bound MITF-M. In addition, not only other MITF isoforms but also TFE3, another member of the family, activated mMCP-9 transcription through this nucleotide sequence inserted one base within the E-box.
- Medical Research Council United Kingdom
- Azabu University Japan
- RIKEN Japan
- MRC Laboratory of Molecular Biology United Kingdom
Male, Transcriptional Activation, Microphthalmia-Associated Transcription Factor, Amino Acid Motifs, Serine Endopeptidases, Melanoma, Experimental, Gene Expression Regulation, Enzymologic, Up-Regulation, DNA-Binding Proteins, Mice, Animals, Humans, Female, Mast Cells, Protein Binding, Transcription Factors
Male, Transcriptional Activation, Microphthalmia-Associated Transcription Factor, Amino Acid Motifs, Serine Endopeptidases, Melanoma, Experimental, Gene Expression Regulation, Enzymologic, Up-Regulation, DNA-Binding Proteins, Mice, Animals, Humans, Female, Mast Cells, Protein Binding, Transcription Factors
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).17 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!