Involvement of galanin in nociceptive regulation in the arcuate nucleus of hypothalamus in rats with mononeuropathy
Copyright policy )Involvement of galanin in nociceptive regulation in the arcuate nucleus of hypothalamus in rats with mononeuropathy
The hindpaw withdrawal latencies (HWLs) to noxious thermal and mechanical stimulation increased significantly after intra-hypothalamic arcuate nucleus (ARC) injection of galanin in mononeuropathic rats, while intra-ARC injection of the putative antagonist of galanin receptors markedly reduced the HWLs. The number of galaninergic neurons in the ARC increased in rats with mononeuropathy than that in normal rats. The results demonstrated that both endogenous and exogenous galanin were involved in the regulation of nociception in the ARC of rats with peripheral nerve injury.
- Peking University China (People's Republic of)
- Peking University China (People's Republic of)
Male, Pain Threshold, Mononeuropathies, Arcuate Nucleus of Hypothalamus, Reaction Time, Animals, Galanin, Rats, Wistar, Rats
Male, Pain Threshold, Mononeuropathies, Arcuate Nucleus of Hypothalamus, Reaction Time, Animals, Galanin, Rats, Wistar, Rats
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