Adoptive Transfer of Allogeneic Antigen-Specific T Cells

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2006 English Publisher:Elsevier BVJournal:Biology of Blood and Marrow Transplantation, volume 12, pages 9-12 (issn: 1083-8791,

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Authors: Riddell, Stanley R.; Bleakley, Marie; Nishida, Tetsuya; Berger, Carolina; Warren, Edus H.;

doi: 10.1016/j.bbmt.2005.10.025

pmid: 16399578

Adoptive Transfer of Allogeneic Antigen-Specific T Cells

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Abstract

Animal models and human studies of allogeneic hematopoietic cell transplantation (HCT) demonstrate that immunologic nonidentity between donor and recipient is responsible for a graft versus leukemia (GVL) effect that contributes to complete tumor eradication. A variety of immune cells have been implicated in the GVL effect including NK cells, B cells, and CD4(+) and CD8(+) T cells that recognize minor histocompatibility (H) or leukemia-associated antigens. Here we discuss strategies for employing T cells specific for minor H antigens to augment the GVL effect.

Related Organizations

Fred Hutchinson Cancer Research Center
South Africa
Fred Hutchinson Cancer Research Center
United States

Keywords

CD4-Positive T-Lymphocytes, Transplantation, B-Lymphocytes, Isoantigens, Adoptive transfer, Hematopoietic Stem Cell Transplantation, Graft vs Leukemia Effect, Hematology, CD8-Positive T-Lymphocytes, Adoptive Transfer, Killer Cells, Natural, Minor Histocompatibility Antigens, T-cell response, Animals, Humans

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